Research suggests cause and possible treatment of NSF
Researchers at Wake Forest University Baptist Medical Center, working with colleagues at other institutions have released findings of their research into why some patients who are in kidney failure also develop a condition known as nephrogenic systemic fibrosis (NSF). NSF has caused tightening and swelling in the skin and other organs, among them the lungs and the heart. They have known that 2 to 4% of patients on dialysis and injected with a contrast agent, gadolinium, prior to an MRI have developed the disease. While they know that the gadolinium causes the problem, until now, it has not been known how. This study suggests that an enzyme named transglutaminase-2, TG2, may play a part.
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